dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project

Soichi Ogishima; Satoshi Nagaie; Satoshi Mizuno; Ryosuke Ishiwata; Keita Iida; Kazuro Shimokawa; Takako Takai-Igarashi; Naoki Nakamura; Sachiko Nagase; Tomohiro Nakamura; Naho Tsuchiya; Naoki Nakaya; Keiko Murakami; Fumihiko Ueno; Tomomi Onuma; Mami Ishikuro; Taku Obara; Shunji Mugikura; Hiroaki Tomita; Akira Uruno; Tomoko Kobayashi; Akito Tsuboi; Shu Tadaka; Fumiki Katsuoka; Akira Narita; Mika Sakurai; Satoshi Makino; Gen Tamiya; Yuichi Aoki; Ritsuko Shimizu; Ikuko N Motoike; Seizo Koshiba; Naoko Minegishi; Kazuki Kumada; Takahiro Nobukuni; Kichiya Suzuki; Inaho Danjoh; Fuji Nagami; Kozo Tanno; Hideki Ohmomo; Koichi Asahi; Atsushi Shimizu; Atsushi Hozawa; Shinichi Kuriyama; Tohoku Medical Megabank Project Study Group; Nobuo Fuse; Teiji Tominaga; Shigeo Kure; Nobuo Yaegashi; Kengo Kinoshita; Makoto Sasaki; Hiroshi Tanaka; Masayuki Yamamoto

doi:10.1038/s41439-021-00175-5

dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project

Hum Genome Var. 2021 Dec 10;8(1):44. doi: 10.1038/s41439-021-00175-5.

Authors

Soichi Ogishima^{1

2

3

4}, Satoshi Nagaie⁵, Satoshi Mizuno⁵, Ryosuke Ishiwata⁵, Keita Iida⁵, Kazuro Shimokawa⁵, Takako Takai-Igarashi⁵, Naoki Nakamura⁶, Sachiko Nagase⁵, Tomohiro Nakamura⁵, Naho Tsuchiya⁵, Naoki Nakaya⁵, Keiko Murakami⁵, Fumihiko Ueno⁵, Tomomi Onuma⁵, Mami Ishikuro⁵, Taku Obara⁵, Shunji Mugikura⁵, Hiroaki Tomita^{7

6

8}, Akira Uruno⁵, Tomoko Kobayashi⁵, Akito Tsuboi⁵, Shu Tadaka⁵, Fumiki Katsuoka^{5

9}, Akira Narita⁵, Mika Sakurai⁵, Satoshi Makino⁵, Gen Tamiya^{5

7}, Yuichi Aoki⁵, Ritsuko Shimizu⁵, Ikuko N Motoike⁵, Seizo Koshiba^{5

9}, Naoko Minegishi⁵, Kazuki Kumada⁵, Takahiro Nobukuni⁵, Kichiya Suzuki⁵, Inaho Danjoh⁵, Fuji Nagami⁵, Kozo Tanno¹⁰, Hideki Ohmomo¹⁰, Koichi Asahi¹⁰, Atsushi Shimizu¹⁰, Atsushi Hozawa⁵, Shinichi Kuriyama^{5

8}; Tohoku Medical Megabank Project Study Group; Nobuo Fuse⁵, Teiji Tominaga^{5

7

6}, Shigeo Kure^{5

7

6}, Nobuo Yaegashi⁵, Kengo Kinoshita^{5

9

11}, Makoto Sasaki¹⁰, Hiroshi Tanaka⁵, Masayuki Yamamoto^{12

13

14}

Collaborators

Tohoku Medical Megabank Project Study Group:
Masayuki Yamamoto, Michiaki Abe, Yayoi Aizawa, Yuichi Aoki, Koichi Chida, Inaho Danjoh, Shinichi Egawa, Ai Eto, Takamitsu Funayama, Nobuo Fuse, Yohei Hamanaka, Yuki Harada, Hiroaki Hashizume, Shinichi Higuchi, Sachiko Hirano, Takumi Hirata, Masahiro Hiratsuka, Atsushi Hozawa, Kazuhiko Igarashi, Jin Inoue, Noriko Ishida, Naoto Ishii, Tadashi Ishii, Mami Ishikuro, Kiyoshi Ito, Sadayoshi Ito, Maiko Kageyama, Fumiki Katsuoka, Hiroshi Kawame, Junko Kawashima, Masahiro Kikuya, Kengo Kinoshita, Kazuyuki Kitatani, Tomomi Kiyama, Hideyasu Kiyomoto, Tomoko Kobayashi, Eiichi Kodama, Mana Kogure, Kaname Kojima, Sachie Koreeda, Seizo Koshiba, Shihoko Koyama, Hisaaki Kudo, Kazuki Kumada, Shigeo Kure, Miho Kuriki, Shinichi Kuriyama, Yoko Kuroki, Norihide Maikusa, Satoshi Makino, Hiroko Matsubara, Hiroyuki Matsui, Hirohito Metoki, Takahiro Mimori, Naoko Minegishi, Kazuharu Misawa, Masako Miyashita, Satoshi Mizuno, Hozumi Motohashi, Ikuko N Motoike, Satoshi Nagaie, Masato Nagai, Fuji Nagami, Masao Nagasaki, Sachiko Nagase, Naoki Nakamura, Tomohiro Nakamura, Naoki Nakaya, Keiko Nakayama, Akira Narita, Ichiko Nishijima, Takahiro Nobukuni, Kotaro Nochioka, Taku Obara, Soichi Ogishima, Noriaki Ohuchi, Gervais Olivier, Noriko Osumi, Hiroshi Otsu, Akihito Otsuki, Daisuke Saigusa, Sakae Saito, Tomo Saito, Masaki Sakaida, Mika Sakurai-Yageta, Yuki Sato, Yukuto Sato, Atsushi Sekiguchi, Chen-Yang Shen, Tomoko F Shibata, Ritsuko Shimizu, Kazuro Shimokawa, Matsuyuki Shirota, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Shu Tadaka, Makiko Taira, Takako Takai-Igarashi, Yuji Takano, Yasuyuki Taki, Gen Tamiya, Osamu Tanabe, Hiroshi Tanaka, Yukari Tanaka, Shunsuke Teraguchi, Takahiro Terakawa, Teiji Tominaga, Hiroaki Tomita, Akito Tsuboi, Naho Tsuchiya, Ichiro Tsuji, Masao Ueki, Akira Uruno, Nobuo Yaegashi, Junya Yamagishi, Yumi Yamaguchi-Kabata, Chizuru Yamanaka, Riu Yamashita, Jun Yasuda, Junji Yokozawa, Kazunori Waki, Makoto Sasaki, Junko Akai, Ryujin Endo, Akimune Fukushima, Ryohei Furukawa, Tsuyoshi Hachiya, Kouhei Hashizume, Jiro Hitomi, Yasushi Ishigaki, Shohei Komaki, Yuka Kotozaki, Takahiro Mikami, Motoyuki Nakamura, Naoyuki Nishiya, Satoshi Nishizuka, Yoko Nomura, Kuniaki Ogasawara, Hideki Ohmomo, Shinichi Omama, Ryo Otomo, Kotaro Otsuka, Kotaro Oyama, Kiyomi Sakata, Ryohei Sasaki, Mamoru Satoh, Namie Sato, Atsushi Shimizu, Yu Shiwa, Yoichi Sutoh, Nobuyuki Takanashi, Noriko Takebe, Fumitaka Tanaka, Ryoichi Tanaka, Kozo Tanno, Tomoharu Tokutomi, Kayono Yamamoto, Fumio Yamashita

Affiliations

¹ Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan. ogishima@megabank.tohoku.ac.jp.
² Graduate School of Medicine, Tohoku University, Sendai, Japan. ogishima@megabank.tohoku.ac.jp.
³ Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan. ogishima@megabank.tohoku.ac.jp.
⁴ Tohoku University Hospital, Tohoku University, Sendai, Japan. ogishima@megabank.tohoku.ac.jp.
⁵ Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
⁶ Tohoku University Hospital, Tohoku University, Sendai, Japan.
⁷ Graduate School of Medicine, Tohoku University, Sendai, Japan.
⁸ International Research Institute of Disaster Science, Tohoku University, Sendai, Japan.
⁹ Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan.
¹⁰ Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Morioka, Japan.
¹¹ Graduate School of Information Sciences, Tohoku University, Sendai, Japan.
¹² Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan. masiyamamoto@med.tohoku.ac.jp.
¹³ Graduate School of Medicine, Tohoku University, Sendai, Japan. masiyamamoto@med.tohoku.ac.jp.
¹⁴ Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan. masiyamamoto@med.tohoku.ac.jp.

Abstract

To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called "dbTMM" that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.

Abstract

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