Parametric fMRI analysis of videos of variable arousal levels reveals different dorsal vs ventral activation preferences between autism and controls

Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov:2021:6412-6415. doi: 10.1109/EMBC46164.2021.9630013.

Abstract

Atypical sensory processing is now considered a ubiquitous feature of autism spectrum disorder (ASD) and is responsible for the atypical sensory-based behaviours seen in these individuals. Specifically, emotional arousal is a critical ASD target since it comprises emotion regulation and sensory processing, two core aspects of autism. So, in this project, we used task-based fMRI and a well-catalogued dataset of videos with variable arousal levels to characterize the sensory processing of emotional arousal content in ASD and typically developed controls. Our analysis revealed a difference in the secondary attention network where ASD individuals showed a clear yet lateralized preference to the dorsal attention network, whereas the neurotypical individuals preferred the ventral attention network.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arousal
  • Autism Spectrum Disorder* / diagnostic imaging
  • Autistic Disorder* / diagnostic imaging
  • Emotions
  • Humans
  • Magnetic Resonance Imaging