Abstract
Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Drug Delivery Systems / instrumentation*
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Drug Development
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Endosomes / drug effects
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Humans
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Ions / chemistry
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Lipids / administration & dosage
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Lipids / chemistry*
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Lipids / pharmacology
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Nanoparticles / administration & dosage
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Nanoparticles / chemistry
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RNA / administration & dosage*
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RNA / chemistry