Osteonecrosis of the humeral head in a human immunodeficiency virus-infected patient under tenofovir disoproxil fumarate-emtricitabine-lopinavir/ritonavir for 10 years: a case report

J Med Case Rep. 2021 Dec 18;15(1):624. doi: 10.1186/s13256-021-03145-1.

Abstract

Background: Human immunodeficiency virus-infected patients are 100 times more likely to develop aseptic osteonecrosis compared with the general population. While 90% of cases concern the femoral head, the involvement of humeral bone remains rare.

Case presentation: We report a case of aseptic osteonecrosis of the left humeral head complicating antiretroviral therapy in a female, 46-year-old, Bissau-Guinean human immunodeficiency virus-infected patient received in a context of progressive pain in the left shoulder followed by limitation of articular movements. Standard x-ray of the shoulder allowed us to make the diagnosis by showing a typical image of osteonecrosis. The treatment was medical combined with physiotherapy.

Conclusions: Aseptic osteonecrosis should be systematically looked for in human immunodeficiency virus patients on antiretroviral treatment. In addition to femoral head aseptic necrosis, the involvement of the humeral bone should also be considered.

Keywords: Antiretroviral therapy; Aseptic osteonecrosis; Case report; HIV-infected patients; Humeral head.

Publication types

  • Case Reports

MeSH terms

  • Emtricitabine
  • Female
  • HIV
  • HIV Infections* / complications
  • HIV Infections* / drug therapy
  • Humans
  • Humeral Head / diagnostic imaging
  • Lopinavir
  • Middle Aged
  • Osteonecrosis* / chemically induced
  • Osteonecrosis* / diagnostic imaging
  • Ritonavir
  • Tenofovir / adverse effects

Substances

  • Lopinavir
  • Tenofovir
  • Emtricitabine
  • Ritonavir