Emergence of Difficult-to-Treat Tinea Corporis Caused by Trichophyton mentagrophytes Complex Isolates, Paris, France

Emerg Infect Dis. 2022 Jan;28(1):224-228. doi: 10.3201/eid2801.210810.

Abstract

We describe 7 cases of extensive tinea corporis since 2018 in a hospital in Paris, France, after failure to cure with terbinafine. Molecular analysis indicated Trichophyton mentagrophytes internal transcribed spacer type VIII (T. indotineae). This strain, which has mutations in the squalene epoxidase gene, is spreading on the Indian subcontinent.

Keywords: France; Trichophyton indotineae; Trichophyton mentagrophytes complex; antifungal drug resistance; antimicrobial resistance; fungi; human-to-human transmission; skin infections; squalene epoxidase; terbinafine.

MeSH terms

  • Antifungal Agents / pharmacology
  • Antifungal Agents / therapeutic use
  • Arthrodermataceae
  • Drug Resistance, Fungal
  • France / epidemiology
  • Humans
  • Paris
  • Tinea* / diagnosis
  • Tinea* / drug therapy
  • Trichophyton* / genetics

Substances

  • Antifungal Agents

Supplementary concepts

  • Trichophyton mentagrophytes