Electrochemical Rearrangement of 3-Hydroxyoxindoles into Benzoxazinones

Org Lett. 2022 Jan 14;24(1):27-32. doi: 10.1021/acs.orglett.1c03569. Epub 2021 Dec 24.

Abstract

We report an unexpected rearrangement of 3-hydroxyoxindoles into benzoxazinones using electrochemistry. Our reaction employs mild and environmentally friendly conditions, and the benzoxazinone products are obtained in moderate to excellent yields. Mechanistic experiments suggest that a peroxide intermediate is likely involved.

Publication types

  • Research Support, Non-U.S. Gov't