Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates

Marieke A Stammes; Ji Hyun Lee; Lisette Meijer; Thibaut Naninck; Lara A Doyle-Meyers; Alexander G White; H Jacob Borish; Amy L Hartman; Xavier Alvarez; Shashank Ganatra; Deepak Kaushal; Rudolf P Bohm; Roger le Grand; Charles A Scanga; Jan A M Langermans; Ronald E Bontrop; Courtney L Finch; JoAnne L Flynn; Claudia Calcagno; Ian Crozier; Jens H Kuhn

doi:10.1016/j.molmed.2021.12.001

Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates

Trends Mol Med. 2022 Feb;28(2):123-142. doi: 10.1016/j.molmed.2021.12.001. Epub 2021 Dec 7.

Authors

Marieke A Stammes¹, Ji Hyun Lee², Lisette Meijer³, Thibaut Naninck⁴, Lara A Doyle-Meyers⁵, Alexander G White⁶, H Jacob Borish⁶, Amy L Hartman⁷, Xavier Alvarez⁸, Shashank Ganatra⁸, Deepak Kaushal⁸, Rudolf P Bohm⁵, Roger le Grand⁴, Charles A Scanga⁹, Jan A M Langermans¹⁰, Ronald E Bontrop¹¹, Courtney L Finch², JoAnne L Flynn⁹, Claudia Calcagno², Ian Crozier¹², Jens H Kuhn²

Affiliations

¹ Biomedical Primate Research Centre (BPRC), 2288 GJ, Rijswijk, The Netherlands. Electronic address: stammes@bprc.nl.
² Integrated Research Facility at Fort Detrick (IRF-Frederick), Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Fort Detrick, Frederick, MD 21702, USA.
³ Biomedical Primate Research Centre (BPRC), 2288 GJ, Rijswijk, The Netherlands.
⁴ Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Université Paris-Saclay, Inserm, CEA, 92260 Fontenay-aux-Roses, France.
⁵ Tulane National Primate Research Center, Covington, LA 70433, USA; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
⁶ Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
⁷ Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pitt Public Health, Pittsburgh, PA 15261, USA.
⁸ Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
⁹ Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA; Center for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
¹⁰ Biomedical Primate Research Centre (BPRC), 2288 GJ, Rijswijk, The Netherlands; Department Population Health Sciences, Division of Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, 3584 CL, Utrecht, The Netherlands.
¹¹ Biomedical Primate Research Centre (BPRC), 2288 GJ, Rijswijk, The Netherlands; Department of Biology, Theoretical Biology and Bioinformatics, Utrecht University, 3584 CH, Utrecht, The Netherlands.
¹² Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.

Abstract

Chest X-ray (CXR), computed tomography (CT), and positron emission tomography-computed tomography (PET-CT) are noninvasive imaging techniques widely used in human and veterinary pulmonary research and medicine. These techniques have recently been applied in studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-exposed non-human primates (NHPs) to complement virological assessments with meaningful translational readouts of lung disease. Our review of the literature indicates that medical imaging of SARS-CoV-2-exposed NHPs enables high-resolution qualitative and quantitative characterization of disease otherwise clinically invisible and potentially provides user-independent and unbiased evaluation of medical countermeasures (MCMs). However, we also found high variability in image acquisition and analysis protocols among studies. These findings uncover an urgent need to improve standardization and ensure direct comparability across studies.

Keywords: COVID-19; SARS-CoV-2; imaging; lung; non-human primate.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
COVID-19*
Humans
Lung / diagnostic imaging
Positron Emission Tomography Computed Tomography
Primates
SARS-CoV-2*

Abstract

Publication types

MeSH terms

Grants and funding