COVID-19 vaccine and autoimmunity. A new case of autoimmune hepatitis and review of the literature

Laura Camacho-Domínguez; Yhojan Rodríguez; Fernando Polo; Juan Carlos Restrepo Gutierrez; Elizabeth Zapata; Manuel Rojas; Juan-Manuel Anaya

doi:10.1016/j.jtauto.2022.100140

COVID-19 vaccine and autoimmunity. A new case of autoimmune hepatitis and review of the literature

J Transl Autoimmun. 2022:5:100140. doi: 10.1016/j.jtauto.2022.100140. Epub 2022 Jan 4.

Authors

Laura Camacho-Domínguez¹, Yhojan Rodríguez^{1

2}, Fernando Polo³, Juan Carlos Restrepo Gutierrez⁴, Elizabeth Zapata¹, Manuel Rojas¹, Juan-Manuel Anaya^{1

2}

Affiliations

¹ Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.
² Clínica del Occidente, Bogota, Colombia.
³ Hospital Infantil de San José, Fundación Universitaria de Ciencias de la Salud. Department of Pathology, Bogota, Colombia.
⁴ Hepatology, Hospital Pablo Tobon Uribe, Medellin, Colombia.

Abstract

Autoimmunity following COVID-19 vaccination has been reported. Herein, a 79-year-old man with clinical and immunological features of autoimmune hepatitis type 1 after ChAdOx1 nCoV-19 vaccination is presented. Clinical manifestations rapidly remitted after the instauration of immunomodulatory management. This case, together with a comprehensive review of the literature, illustrates the association between COVID-19 vaccines and the development of autoimmune conditions.

Keywords: AZD1222; AstraZeneca; Autoimmune hepatitis; COVID-19; ChAdOx1 nCoV-19; SARS-CoV-2.

Publication types

Case Reports