Lupus nephritis and beyond: Kidney-intrinsic genetic risk for antibody deposition

Irene Chernova; Joe Craft

doi:10.1016/j.xcrm.2021.100479

Lupus nephritis and beyond: Kidney-intrinsic genetic risk for antibody deposition

Cell Rep Med. 2021 Dec 21;2(12):100479. doi: 10.1016/j.xcrm.2021.100479.

Authors

Irene Chernova¹, Joe Craft^{2

3}

Affiliations

¹ Section of Nephrology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
² Section of Rheumatology, Allergy, and Immunology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA.
³ Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.

Abstract

Antibody deposition is a defining pathological feature of multiple kidney diseases including lupus nephritis. In this issue of Cell Reports Medicine, Jiang and colleagues¹ identify a novel genetic risk factor, VANGL1, which predisposes individuals toward antibody deposition via a kidney-intrinsic mechanism.

Publication types

Comment

MeSH terms

Carrier Proteins
Humans
Kidney
Lupus Nephritis* / genetics
Membrane Proteins
Risk Factors

Substances

Carrier Proteins
Membrane Proteins
VANGL1 protein, human

Abstract

Publication types

MeSH terms

Substances

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