Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission Dynamics and Immune Responses in a Household of Vaccinated Persons

Jamin Liu; Matthew T Laurie; Luis Rubio; Sara E Vazquez; Sara Sunshine; Anthea M Mitchell; Matthias Hapte-Selassie; Sabrina A Mann; Genay Pilarowski; Douglas Black; Carina Marquez; Susana Rojas; Michail S Lionakis; Maya Petersen; Jeffrey D Whitman; Vivek Jain; Mark Anderson; Diane Havlir; Joseph DeRisi

doi:10.1093/cid/ciac029

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission Dynamics and Immune Responses in a Household of Vaccinated Persons

Clin Infect Dis. 2022 Aug 24;75(1):e303-e306. doi: 10.1093/cid/ciac029.

Authors

Jamin Liu^{1

2}, Matthew T Laurie², Luis Rubio³, Sara E Vazquez^{2

4}, Sara Sunshine², Anthea M Mitchell^{2

5}, Matthias Hapte-Selassie^{2

5}, Sabrina A Mann^{2

5}, Genay Pilarowski^{6

7}, Douglas Black³, Carina Marquez³, Susana Rojas⁷, Michail S Lionakis⁸, Maya Petersen⁹, Jeffrey D Whitman¹⁰, Vivek Jain³, Mark Anderson⁴, Diane Havlir³, Joseph DeRisi^{2

5}

Affiliations

¹ University of California, Berkeley-University of California, San Francisco Graduate Program in Bioengineering, Berkeley, California, USA.
² Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA.
³ Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, California, USA.
⁴ Department of Medicine, Diabetes Center, University of California, San Francisco, San Francisco, California, USA.
⁵ Chan Zuckerberg Biohub, San Francisco, California, USA.
⁶ The Public Health Company, Oakland, California, USA.
⁷ Unidos en Salud, San Francisco, California, USA.
⁸ Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
⁹ Division of Biostatistics, University of California, Berkeley, Berkeley, California, USA.
¹⁰ Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA.

Abstract

While SARS-CoV-2 vaccines prevent severe disease effectively, postvaccination "breakthrough" COVID-19 infections and transmission among vaccinated individuals remain ongoing concerns. We present an in-depth characterization of transmission and immunity among vaccinated individuals in a household, revealing complex dynamics and unappreciated comorbidities, including autoimmunity to type 1 interferon in the presumptive index case.

Keywords: SARS-CoV-2; anti; antibody neutralization; autoimmunity; breakthrough infection; interferon autoantibody.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural

MeSH terms

Antibodies, Viral
COVID-19 Vaccines
COVID-19* / prevention & control
Humans
Immunity
SARS-CoV-2*

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission Dynamics and Immune Responses in a Household of Vaccinated Persons

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