[A Case of G-CSF Producing Esophageal Carcinosarcoma Treated Effectively with Nivolumab for Recurrences following Two-Stage Surgery]

Gan To Kagaku Ryoho. 2021 Dec;48(13):2112-2114.
[Article in Japanese]

Abstract

G-CSF producing esophageal carcinosarcoma is extremely rare, and its effective treatment strategy remains undefined. Here, we report the case of a 69-year-old woman who underwent successful two-stage surgery using mediastinoscopic esophagectomy and laparoscopic reconstruction for the management of severe anemia, malnutrition, and inflammation due to G-CSF producing esophageal carcinosarcoma(G-CSF 265 pg/mL). Chemoradiotherapy could not manage lymph node recurrences in the patient; however, nivolumab was found to be effective and helped achieved a prolonged partial response.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Carcinosarcoma* / drug therapy
  • Carcinosarcoma* / surgery
  • Esophageal Neoplasms* / drug therapy
  • Esophageal Neoplasms* / surgery
  • Esophagectomy
  • Female
  • Granulocyte Colony-Stimulating Factor
  • Humans
  • Nivolumab / therapeutic use
  • Recurrence

Substances

  • Granulocyte Colony-Stimulating Factor
  • Nivolumab