Adaptive differentiation for fast barrier restoration

Qiutan Yang; Prisca Liberali

doi:10.1016/j.devcel.2021.12.024

Adaptive differentiation for fast barrier restoration

Dev Cell. 2022 Jan 24;57(2):147-148. doi: 10.1016/j.devcel.2021.12.024.

Authors

Qiutan Yang¹, Prisca Liberali²

Affiliations

¹ Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, 4058 Basel, Switzerland.
² Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, 4058 Basel, Switzerland. Electronic address: prisca.liberali@fmi.ch.

PMID: 35077677
DOI: 10.1016/j.devcel.2021.12.024

Abstract

Epithelial regeneration can be mediated through activation of stem cells or de-differentiation of post-mitotic cells. In this issue of Developmental Cell, Ohara et al. report that regeneration of damaged intestinal villi occurs via a yes-associated protein 1 (YAP)-dependent adaptive differentiation of transit-amplifying progenitors to a fetal-like state that restores intestinal barrier function.

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MeSH terms

Cell Differentiation
Intestinal Mucosa*
Stem Cells*