Hypersensitivity reactions to vaccines in children: from measles to SARS-CoV-2

Pediatr Allergy Immunol. 2022 Jan;33 Suppl 27(Suppl 27):58-60. doi: 10.1111/pai.13631.

Abstract

Allergic individuals at risk for hypersensitivity reactions to measles vaccine marketed for a long time are well established. On the other hand, risk factors for hypersensitivity reactions to the new mRNA COVID-19 vaccines currently include a history of allergy, allergy to excipient of the vaccine, or hypersensitivity reactions to the first dose of COVID-19 vaccine. In the last two cases, the recipient should be assessed by an allergist before vaccination to share a decision on the choice of vaccination. Studies on skin testing accuracy and desensitization protocols to the COVID-19 vaccines and the efficacy of potential alternatives in patients with confirmed hypersensitivity reactions to the first COVID-19 vaccine are necessary to improve the safety of COVID-19 vaccines.

Keywords: COVID-19; SARS-CoV-2; children; hypersensitivity reaction; influenza; measles; vaccine; yellow fever.

MeSH terms

  • COVID-19 Vaccines
  • COVID-19*
  • Child
  • Humans
  • Hypersensitivity* / etiology
  • Measles* / prevention & control
  • SARS-CoV-2
  • Vaccination / adverse effects
  • Vaccines*

Substances

  • COVID-19 Vaccines
  • Vaccines