Regioselective synthesis of 6-nitroindole derivatives from enaminones and nitroaromatic compounds via transition metal-free C-C and C-N bond formation

Danhua Ge; Li-Wen Sun; Zi-Lun Yu; Xin-Long Luo; Pei Xu; Zhi-Liang Shen

doi:10.1039/d1ob02443d

Regioselective synthesis of 6-nitroindole derivatives from enaminones and nitroaromatic compounds via transition metal-free C-C and C-N bond formation

Org Biomol Chem. 2022 Feb 16;20(7):1493-1499. doi: 10.1039/d1ob02443d.

Authors

Danhua Ge¹, Li-Wen Sun¹, Zi-Lun Yu¹, Xin-Long Luo¹, Pei Xu², Zhi-Liang Shen¹

Affiliations

¹ Chemical Experiment Teaching Center, Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China. gedanhua@njtech.edu.cn.
² Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China. xupei@xzhmu.edu.cn.

PMID: 35107115
DOI: 10.1039/d1ob02443d

Abstract

Few methods are known for the synthesis of nitroindole derivatives. A simple and practical Cs₂CO₃-promoted method for the synthesis of 6-nitroindole derivatives from enaminones and nitroaromatic compounds has been developed. Two new C-C and C-N bonds were formed in a highly regioselective manner under transition metal-free conditions.

Publication types

Research Support, Non-U.S. Gov't