Green tea polyphenols inhibit growth, pathogenicity and metabolomics profiles of Streptococcus suis

Ting Gao; Fei Ye; Fangyan Yuan; Zewen Liu; Wei Liu; Danna Zhou; Keli Yang; Rui Guo; Ningning Wang; Tengfei Zhang; Rui Zhou; Yongxiang Tian

doi:10.1016/j.micpath.2022.105421

Green tea polyphenols inhibit growth, pathogenicity and metabolomics profiles of Streptococcus suis

Microb Pathog. 2022 Mar:164:105421. doi: 10.1016/j.micpath.2022.105421. Epub 2022 Feb 1.

Authors

Ting Gao¹, Fei Ye², Fangyan Yuan¹, Zewen Liu¹, Wei Liu¹, Danna Zhou¹, Keli Yang¹, Rui Guo¹, Ningning Wang³, Tengfei Zhang¹, Rui Zhou⁴, Yongxiang Tian⁵

Affiliations

¹ Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry of Agriculture and Rural Affairs), Hubei Provincial Key Laboratory of Animal Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China.
² Institute of Fruit and Tea, Hubei Academy of Agricultural Sciences, Wuhan, China.
³ Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry of Agriculture and Rural Affairs), Hubei Provincial Key Laboratory of Animal Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Cooperative Innovation Center of Sustainable Pig Production, Wuhan, China.
⁴ State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Cooperative Innovation Center of Sustainable Pig Production, Wuhan, China. Electronic address: rzhou@mail.hzau.edu.cn.
⁵ Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry of Agriculture and Rural Affairs), Hubei Provincial Key Laboratory of Animal Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China. Electronic address: tyxanbit@163.com.

PMID: 35114350
DOI: 10.1016/j.micpath.2022.105421

Abstract

Streptococcus suis (SS) is an important pathogen in pigs and can also cause severe infection in humans. Currently, more and more drug resistance is reported, resulting in the search for new drugs being needed urgently. Green tea polyphenols (GTP) was reported to inhibit many bacteria. However, SS response to GTP has not been studied before. In this report, the effect of GTP on growth, cell integrity, pathogenicity and metabolic pathway of SS was examined. The GTP inhibited growth, led to cellular damage, and attenuated pathogenicity of SS. Finally, GTP affected many important metabolic pathways of SS, such as ABC transporters, pyrimidine metabolism, protein digestion and absorption. The results provide new insight into the prevention and control of SS infection.

Keywords: Green tea polyphenols; Growth; Pathogenicity; Streptococcus suis; Untargeted metabolomics.

MeSH terms

Animals
Metabolomics
Polyphenols / pharmacology
Streptococcus suis*
Swine
Tea
Virulence

Substances

Polyphenols
Tea