Hepatobiliary tumor organoids for personalized medicine: a multicenter view on establishment, limitations, and future directions

Gilles S van Tienderen; Ling Li; Laura Broutier; Yoshimasa Saito; Patricia Inacio; Meritxell Huch; Florin M Selaru; Luc J W van der Laan; Monique M A Verstegen

doi:10.1016/j.ccell.2022.02.001

Hepatobiliary tumor organoids for personalized medicine: a multicenter view on establishment, limitations, and future directions

Cancer Cell. 2022 Mar 14;40(3):226-230. doi: 10.1016/j.ccell.2022.02.001. Epub 2022 Feb 10.

Authors

Gilles S van Tienderen¹, Ling Li², Laura Broutier³, Yoshimasa Saito⁴, Patricia Inacio³, Meritxell Huch³, Florin M Selaru⁵, Luc J W van der Laan⁶, Monique M A Verstegen¹

Affiliations

¹ Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.
² Division of Gastroenterology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
³ The Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, UK.
⁴ Division of Pharmacotherapeutics, Keio University Faculty of Pharmacy, Tokyo, Japan.
⁵ Division of Gastroenterology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA. Electronic address: fselaru1@jhmi.edu.
⁶ Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands. Electronic address: l.vanderlaan@erasmusmc.nl.

PMID: 35148815
DOI: 10.1016/j.ccell.2022.02.001

Abstract

Reliable establishment of tumor organoids is paramount to advance applications of organoid technology for personalized medicine. Here, we share our multi-center experience on initiation and tumorigenic confirmation of hepatobiliary cancer organoids. We discuss current concerns, propose potential solutions, and provide future perspectives for improvements in hepatobiliary cancer organoid establishment.

Hepatobiliary tumor organoids for personalized medicine: a multicenter view on establishment, limitations, and future directions

Authors

Affiliations

Abstract

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