Iridium-catalyzed asymmetric double allylic alkylation of azlactone: efficient access to chiral α-amino acid derivatives

Chem Commun (Camb). 2022 Mar 3;58(19):3142-3145. doi: 10.1039/d2cc00328g.

Abstract

An unprecedented Ir-catalyzed enantioselective double allylic alkylation of less bulky cyclic imine glycinate (azlactone) was rationally designed and developed, providing various bisallylated chiral amino acid derivatives. Control experiments revealed that this transformation proceeds in a sequential manner featuring quasi-dynamic kinetic resolution of the initially-formed monoallylation intermediates.

MeSH terms

  • Alkylation
  • Allyl Compounds / chemistry*
  • Amino Acids / chemical synthesis*
  • Amino Acids / chemistry
  • Catalysis
  • Iridium / chemistry*
  • Lactones / chemistry*
  • Molecular Structure
  • Stereoisomerism

Substances

  • Allyl Compounds
  • Amino Acids
  • Lactones
  • Iridium