Long-Term Effect of PNPLA3 on the Aggravation of Nonalcoholic Fatty Liver Disease in a Biopsy-Proven Cohort

Bo Kyung Koo; Hyunsuk Lee; Soo-Heon Kwak; Dong Hyeon Lee; Jeong Hwan Park; Won Kim; Innovative Target Exploration of NAFLD (ITEN) consortium

doi:10.1016/j.cgh.2022.02.026

Long-Term Effect of PNPLA3 on the Aggravation of Nonalcoholic Fatty Liver Disease in a Biopsy-Proven Cohort

Clin Gastroenterol Hepatol. 2023 Apr;21(4):1105-1107.e3. doi: 10.1016/j.cgh.2022.02.026. Epub 2022 Feb 18.

Authors

Bo Kyung Koo¹, Hyunsuk Lee², Soo-Heon Kwak², Dong Hyeon Lee³, Jeong Hwan Park⁴, Won Kim⁵; Innovative Target Exploration of NAFLD (ITEN) consortium

Affiliations

¹ Division of Endocrinology, Department of Internal Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.
² Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
³ Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Republic of Korea.
⁴ Department of Pathology, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Republic of Korea.
⁵ Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Republic of Korea. Electronic address: drwon1@snu.ac.kr.

PMID: 35189385
DOI: 10.1016/j.cgh.2022.02.026

Abstract

The PNPLA3 rs738409 G allele increases the risk of not only nonalcoholic fatty liver disease (NAFLD) but also nonalcoholic steatohepatitis (NASH) or fibrosis.¹ It also affects the prognosis of patients with NAFLD in specific conditions. After liver transplantation, patients with NAFLD carrying the rs738409 GG genotype have a higher risk of graft steatosis² or development of hepatocellular carcinoma.³ In addition, rs738409 modifies the effects of medical intervention: patients with NAFLD carrying the GG genotype showed a lower effect of omega-3 polyunsaturated fatty acid treatment on the reduction of liver fat;⁴ in contrast, they were more sensitive to the beneficial effects of lifestyle modifications.^5,6.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biopsy
Genetic Predisposition to Disease
Genotype
Humans
Liver / pathology
Liver Neoplasms* / pathology
Non-alcoholic Fatty Liver Disease* / genetics
Non-alcoholic Fatty Liver Disease* / pathology
Polymorphism, Single Nucleotide