Synthesis of polycyclic aminal heterocycles via decarboxylative cyclisation of dipeptide derivatives

Chem Commun (Camb). 2022 Mar 10;58(21):3473-3476. doi: 10.1039/d2cc00167e.

Abstract

An oxidative-decarboxylative intramolecular cyclisation of dipeptide derivatives is reported. This transformation is promoted by phenyl iodine(III) diacetate (PIDA) in combination with BF3·OEt2. The reaction gives access to a variety of valuable polycyclic N-heterocyclic scaffolds containing 5-, 6-, or 7-membered rings.

MeSH terms

  • Cyclization
  • Dipeptides
  • Heterocyclic Compounds* / chemistry
  • Iodine*
  • Oxidation-Reduction

Substances

  • Dipeptides
  • Heterocyclic Compounds
  • Iodine