Clinicopathological characteristics of colorectal serrated polyposis syndrome (SPS): results of a multicenter study by the SPS Study Group in Japan

Yasutsugu Shimohara; Yuji Urabe; Shiro Oka; Takashi Hisabe; Atsushi Yamada; Hiro-O Matsushita; Bunichiro Kato; Hirotsugu Sakamoto; Joichiro Horii; Daisuke Watanabe; Hirotsugu Eda; Fumika Nakamura; Akiko Chino; Hironori Yamamoto; Tetsuji Takayama; Takayuki Matsumoto; Hideki Ishikawa; Shinji Tanaka

doi:10.1007/s00535-022-01859-7

Clinicopathological characteristics of colorectal serrated polyposis syndrome (SPS): results of a multicenter study by the SPS Study Group in Japan

J Gastroenterol. 2022 Apr;57(4):300-308. doi: 10.1007/s00535-022-01859-7. Epub 2022 Feb 24.

Authors

Yasutsugu Shimohara¹, Yuji Urabe², Shiro Oka¹, Takashi Hisabe³, Atsushi Yamada⁴, Hiro-O Matsushita⁵, Bunichiro Kato⁵, Hirotsugu Sakamoto⁶, Joichiro Horii⁷, Daisuke Watanabe⁸, Hirotsugu Eda⁹, Fumika Nakamura¹⁰, Akiko Chino¹¹, Hironori Yamamoto⁶, Tetsuji Takayama¹⁰, Takayuki Matsumoto¹², Hideki Ishikawa¹³, Shinji Tanaka¹⁴

Affiliations

¹ Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.
² Division of Regeneration and Medicine Center for Translational and Clinical Research, Hiroshima University Hospital, 1-2-3, Kasumi, Minamiku, Hiroshima, 734-8551, Japan. beyan13@hiroshima-u.ac.jp.
³ Department of Gastroenterology, Fukuoka University Chikushi Hospital, Chikushino, Japan.
⁴ Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
⁵ Department of Gastroenterology, Akita Red Cross Hospital, Akita, Japan.
⁶ Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan.
⁷ Department of Gastroenterology, Fukuyama Medical Center, National Hospital Organization, Hiroshima, Japan.
⁸ Division of Gastroenterology, Department of Internal Medicine, Kobe University, Kobe, Japan.
⁹ Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
¹⁰ Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
¹¹ Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
¹² Division of Gastroenterology, Department of Medicine, Iwate Medical University, Iwate, Japan.
¹³ Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
¹⁴ Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.

PMID: 35201414
DOI: 10.1007/s00535-022-01859-7

Abstract

Background: Serrated polyposis syndrome (SPS), a type of colorectal polyposis characterized by multiple serrated polyps, is associated with a high risk of colorectal carcinoma (CRC). This study aimed to clarify the clinicopathological characteristics of SPS in Japan.

Methods: We investigated the clinicopathological characteristics of patients with SPS from the "Multicenter Study on Clinicopathological Characteristics of SPS (UMIN 000032138)" by the Colorectal Serrated Polyposis Syndrome (SPS) Study Group. In this study, patients were diagnosed with SPS based on the 2019 World Health Organization (WHO) SPS diagnostic criteria.

Results: Ninety-four patients were diagnosed with SPS in 10 institutions between January 2001 and December 2017. The mean number (± standard deviation [SD]) of resected lesions per patient was 11.3 ± 13.8. The mean age at diagnosis of SPS was 63.3 ± 11.6 years, and 58 patients (61.7%) were male. Eighty-seven (92.6%) and 16 (17.0%) patients satisfied WHO diagnostic criteria I and II, respectively. Nine patients (9.6%) satisfied both criteria I and II. Carcinoma (T1-T4) were observed in 21 patients (22.3%) and 24 lesions. Of the 21 patients with CRC, 19 (90.4%) satisfied diagnostic criterion I, 1 (4.8%) satisfied diagnostic criterion II, and 1 (4.8%) satisfied diagnostic criteria I and II. There was no notable difference in the prevalence of CRC among patients who met diagnostic criterion I, II, and both I and II.

Conclusions: Patients with SPS have a high risk of CRC and should undergo regular surveillance colonoscopy. Raising awareness of this syndrome is crucial.

Keywords: Colorectal carcinoma (CRC); Serrated polyposis syndrome (SPS); Surveillance colonoscopy.

Publication types

Multicenter Study

MeSH terms

Adenomatous Polyposis Coli* / diagnosis
Adenomatous Polyposis Coli* / epidemiology
Adenomatous Polyposis Coli* / surgery
Colonic Polyps* / diagnosis
Colonic Polyps* / epidemiology
Colonic Polyps* / surgery
Colonoscopy / methods
Colorectal Neoplasms* / diagnosis
Colorectal Neoplasms* / epidemiology
Colorectal Neoplasms* / pathology
Female
Humans
Intestinal Polyposis* / diagnosis
Intestinal Polyposis* / epidemiology
Japan / epidemiology
Male
Syndrome