A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS-CoV-2 Variants of Concern

Zijie Zhang; Jiuxing Li; Jimmy Gu; Ryan Amini; Hannah D Stacey; Jann C Ang; Dawn White; Carlos D M Filipe; Karen Mossman; Matthew S Miller; Bruno J Salena; Deborah Yamamura; Payel Sen; Leyla Soleymani; John D Brennan; Yingfu Li

doi:10.1002/chem.202200524

A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS-CoV-2 Variants of Concern

Chemistry. 2022 Mar 10;28(15):e202200524. doi: 10.1002/chem.202200524. Epub 2022 Feb 26.

Authors

Zijie Zhang¹, Jiuxing Li¹, Jimmy Gu¹, Ryan Amini¹, Hannah D Stacey^{1

2

3}, Jann C Ang^{1

2

3}, Dawn White⁴, Carlos D M Filipe⁵, Karen Mossman⁶, Matthew S Miller^{1

2

3}, Bruno J Salena⁶, Deborah Yamamura^{2

7}, Payel Sen⁸, Leyla Soleymani⁸, John D Brennan⁴, Yingfu Li^{1

4

2

8}

Affiliations

¹ Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada.
² Michael G. DeGroote Institute of Infectious Disease Research, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada.
³ McMaster Immunology Research Centre, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada.
⁴ Biointerfaces Institute, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada.
⁵ Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada.
⁶ Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada.
⁷ Department of Pathology and Molecular Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada.
⁸ School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada.

Abstract

Invited for the cover of this issue are John Brennan, Yingfu Li, and co-workers at McMaster University. The image depicts MSA52 as a universal DNA aptamer that recognizes spike proteins of diverse SARS-CoV-2 variants of concern. Read the full text of the article at 10.1002/chem.202200078.