The polysaccharide-peptide complex from mushroom Cordyceps militaris ameliorates atherosclerosis by modulating the lncRNA-miRNA-mRNA axis

Food Funct. 2022 Mar 21;13(6):3185-3197. doi: 10.1039/d1fo03285b.

Abstract

An N-glycosidic polysaccharide-peptide complex CMPS-80 was obtained from the fruiting body of C. militaris. Of importance, CMPS-80 significantly ameliorated formation of atherosclerotic lesions and plasma lipid profiles in apolipoprotein E-deficient mice. Integrated informatics analysis suggested that CMPS-80 can modulate multiple lncRNA-microRNA-mRNA axes. CMPS-80 has a potential application for prevention of hyperlipidemia and atherosclerosis.

MeSH terms

  • Animals
  • Atherosclerosis / genetics
  • Atherosclerosis / metabolism
  • Atherosclerosis / prevention & control*
  • Cholesterol / blood
  • Cordyceps / chemistry*
  • Coronary Artery Disease / metabolism
  • Coronary Artery Disease / prevention & control
  • Fungal Proteins / chemistry
  • Fungal Proteins / pharmacology*
  • Gene Expression
  • Liver / metabolism
  • Mice
  • MicroRNAs / genetics*
  • Oligonucleotide Array Sequence Analysis
  • Peptides / chemistry
  • Peptides / pharmacology
  • Polysaccharides / chemistry
  • Polysaccharides / pharmacology*
  • Proteoglycans
  • RNA, Long Noncoding / genetics*
  • RNA, Long Noncoding / metabolism
  • RNA, Messenger / genetics*
  • RNA, Messenger / metabolism
  • Triglycerides / blood

Substances

  • Fungal Proteins
  • MicroRNAs
  • Peptides
  • Polysaccharides
  • Proteoglycans
  • RNA, Long Noncoding
  • RNA, Messenger
  • Triglycerides
  • polysaccharide peptide
  • Cholesterol