Tau talk - synaptic and mitochondrial proteins interact with Tau in human neurons

Declan King; Tara L Spires-Jones

doi:10.1016/j.tins.2022.02.004

Tau talk - synaptic and mitochondrial proteins interact with Tau in human neurons

Trends Neurosci. 2022 May;45(5):339-341. doi: 10.1016/j.tins.2022.02.004. Epub 2022 Feb 26.

Authors

Declan King¹, Tara L Spires-Jones²

Affiliations

¹ UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK. Electronic address: declan.king@ed.ac.uk.
² UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.

PMID: 35232606
DOI: 10.1016/j.tins.2022.02.004

Abstract

In a recent study, Tracy, Madero-Pérez, Swaney, et al. observed that Tau interacts with mitochondrial and presynaptic vesicle proteins in human iPSC-derived neurons. Tau with mutations that cause neurodegeneration has decreased mitochondrial interactions. This elegant interactome mapping with supporting human brain data paves the way to a better understanding of Tau pathology and future Tau-directed therapeutics.

Keywords: Alzheimer's disease; MAPT; dementia; human iPSC-derived neurons; tauopathies.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Brain / metabolism
Humans
Induced Pluripotent Stem Cells* / metabolism
Induced Pluripotent Stem Cells* / pathology
Mitochondrial Proteins* / metabolism
Neurons / metabolism
tau Proteins / metabolism

Substances

Mitochondrial Proteins
tau Proteins

Grants and funding

MRC_/Medical Research Council/United Kingdom