Molecular physiology of copper in Drosophila melanogaster

Abstract

In this review, I look at advances made in our understanding of the molecular physiology of copper homeostasis in the vinegar fly Drosophila melanogaster over the past five years, focussing in particular on the most recent 24 months. Firstly, I review publications investigating the physiological and genetic basis of dietary copper toxicity and tolerance, with particular attention paid to the identification of novel transcriptional and post translational regulators of copper homeostasis. Then I hone in on the growing body of evidence linking copper dysregulation with aberrant neuronal development and function.