Enhanced hepatic clearance of hyposialylated platelets explains thrombocytopenia in GNE-related macrothrombocytopenia
Blood Adv
.
2022 Jun 14;6(11):3347-3351.
doi: 10.1182/bloodadvances.2021006830.
Authors
Tessa Noordermeer
1
,
Ivar van Asten
1
2
,
Roger E G Schutgens
1
,
Anke J Lakerveld
2
,
Cornelis A Koekman
2
,
Kay Y Hage
2
,
Silvie A E Sebastian
2
,
Albert Huisman
2
,
Dave J van den Heuvel
3
,
Hans C Gerritsen
3
,
Suzanne J A Korporaal
2
,
Marc Bierings
4
5
,
Jasper J van der Smagt
6
,
Mariëlle E van Gijn
6
,
Rolf T Urbanus
1
Affiliations
1
Center for Benign Haematology, Thrombosis and Haemostasis, Van Creveldkliniek, and.
2
Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
3
Department of Molecular Biophysics, Utrecht University, Utrecht, The Netherlands.
4
Department of Stem Cell Transplantation, Utrecht University Children's Hospital, Utrecht University, Utrecht, The Netherlands.
5
Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands; and.
6
Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
PMID:
35255501
PMCID:
PMC9198933
DOI:
10.1182/bloodadvances.2021006830
No abstract available
Publication types
Research Support, Non-U.S. Gov't
MeSH terms
Anemia*
Blood Platelets
Humans
Platelet Count
Thrombocytopenia*