Background: In humans, basaloid follicular hamartomas are benign follicular tumours, that can be solitary or multiple, in which case they show autosomal dominant inheritance.
Hypothesis/objectives: This study describes clinical and histopathological findings observed in a young cat, which could be consistent with basaloid follicular hamartomas.
Case description: Multiple follicular abnormalities, consistent with cutaneous diffuse basaloid follicular hamartomas, were observed in skin samples from a one-year old neutered domestic short hair cat. Clinical signs were diffuse symmetrical alopecia with exaggerated skin markings (ventral abdomen, thorax and medial aspects of the limbs) and intense follicular-centred thickening (face and feet). Microscopic lesions were characterised by multiple proliferative follicular abnormalities in all samples. The epidermis showed a very irregular surface with the follicles filled with variably pigmented keratin. The epithelial walls of the follicles had multiple small hyperplastic basaloid cells foci. In the superficial dermis under the epidermis and around the follicles, fibroblastic spindle-shaped mesenchymal cells with a homogeneous moderate density were present in the collagenous connective tissue. The interfollicular epidermis was also abnormal with multiple small proliferating trichoblastic foci originating from the basal layer. RNAscope testing for feline papillomavirus was negative.
Conclusions and clinical relevance: This case report provides the first evidence of clinical and histopathological findings of multiple follicular abnormalities, consistent with cutaneous diffuse basaloid follicular hamartomas in a cat.
在一只1岁去势家养短毛猫的皮肤样本中观察到多发性毛囊异常,与皮肤弥漫性基底样毛囊错构瘤一致。临床体征为弥漫性对称性脱毛, 伴皮肤纹理加深(下腹部、胸部和四肢内侧) 和明显的的毛囊中心增厚 (面部和爪部) 。.
De multiples anomalies folliculaires, compatibles avec des hamartomes folliculaires basaloïdes diffus cutanés, ont été observées dans des échantillons de peau d'un chat domestique à poils courts castré âgé d'un an. Les signes cliniques étaient une alopécie diffuse symétrique avec des marques cutanées exagérées (abdomen ventral, thorax et face médiale des membres) et un épaississement folliculaire intense (face et pieds).
In Hautproben einer einjährigen kastrierten Europäischen Kurzhaarkatze wurden multiple follikuläre Abnormaitäten beobachtet, die mit kutanen diffusen follikulären Hamartomen konsistent waren. Die klinischen Zeichen bestanden aus einer diffusen symmetrischen Alopezie mit übertriebenen Markierungen auf der Haut (ventrales Abdomen, Thorax und mediale Aspekte der Extremitäten) sowie deutliche Follikel-zentrierte Verdickungen (Gesicht und Füsse).
1歳の去勢されたドメスティック・ショートヘアの猫の皮膚に、皮膚びまん性basaloid follicular hamartomaに一致する複数の毛包異常が観察された。臨床症状は、強調された皮膚の模様を伴うびまん性対称性脱毛 (腹部腹側、胸部、四肢内側) および強い毛包中心性肥厚 (顔面、足部) であった。.
Múltiplas anormalidades foliculares, consistentes com hamartomas cutâneos foliculares basaloides difusos, foram observadas em amostras de pele de um gato doméstico de pelo curto castrado de um ano de idade. Os sinais clínicos foram alopecia simétrica difusa com marcações cutâneas exuberantes (abdômen, tórax e aspecto medial dos membros) e espessamento folicular central intenso (face e patas).
Se observaron múltiples anomalías foliculares, consistentes con hamartomas foliculares basaloides difusos cutáneos, en muestras de piel de un gato doméstico de pelo corto castrado de 1 año. Los signos clínicos fueron alopecia simétrica difusa con marcas cutáneas exageradas (abdomen ventral, tórax y cara medial de las extremidades) e intenso engrosamiento de la piel centrado en los folículos (cara y pies).
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