Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos

Cell Discov. 2022 Mar 18;8(1):27. doi: 10.1038/s41421-022-00391-5.

Yinghui Wei^#^{1

2}, Zhifang Li^#¹, Kui Xu^#¹, Hu Feng^#¹, Long Xie^#¹, Di Li¹, Zhenrui Zuo¹, Meiling Zhang³, Chunlong Xu⁴, Hui Yang^{5

6}, Erwei Zuo⁷

¹ Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong, China.
² Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
³ International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. zhml1119@sina.com.
⁴ Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Lingang Laboratory, Shanghai, China. xucl@bsbii.cn.
⁵ Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. huiyang@ion.ac.cn.
⁶ Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Lingang Laboratory, Shanghai, China. huiyang@ion.ac.cn.
⁷ Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong, China. zuoerwei@caas.cn.

^# Contributed equally.

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