Development of Venous Thromboembolism After COVID-19 mRNA-1273 Vaccine Inoculation

Abdullahi E Mahgoub; Dominic Awuah; MurtazaShabbir Hussain; Smit Deliwala; Ghassan Bachuwa; Mariam Younas

doi:10.7759/cureus.22179

Development of Venous Thromboembolism After COVID-19 mRNA-1273 Vaccine Inoculation

Cureus. 2022 Feb 13;14(2):e22179. doi: 10.7759/cureus.22179. eCollection 2022 Feb.

Authors

Abdullahi E Mahgoub^{1

2}, Dominic Awuah^{1

2}, MurtazaShabbir Hussain^{1

2}, Smit Deliwala^{1

2}, Ghassan Bachuwa^{1

2}, Mariam Younas^{3

2}

Affiliations

¹ Internal Medicine, Hurley Medical Center, Flint, USA.
² College of Human Medicine, Michigan State University, Lansing, USA.
³ Infectious Diseases, Hurley Medical Center, Flint, USA.

Abstract

A 79-year-old man suddenly developed right lower extremity (RLE) pain and swelling a few days after receiving his 1st dose of the mRNA-1273 COVID-19 vaccine. Despite this, he proceeded to receive the 2nd dose of his mRNA-1273 COVID-19 vaccine. Investigations confirmed extensive acute deep venous thrombosis and a concurrent acute pulmonary embolism. Therapeutic anticoagulation was initiated and he was eventually discharged home on supplemental oxygen. The overall benefits of the vaccine in curbing severe disease overwhelmingly outweigh the handful of cases of reported adverse events. To our knowledge, this is one of the first few cases of provoked venous thrombosis after receiving the mRNA-1273 COVID-19 vaccine during the pharmacovigilance period.

Keywords: covid vaccines; covid-19; mrna-1273 vaccine; vaccine induced thrombosis; venous thromboembolism.

Publication types

Case Reports