Association of Plasma Circulating Tumor HPV DNA With HPV-Related Oropharynx Cancer

Sakshi R Tewari; Gypsyamber D'Souza; Tanya Troy; Hannah Wright; Linda Struijk; Tim Waterboer; Carole Fakhry

doi:10.1001/jamaoto.2022.0159

Association of Plasma Circulating Tumor HPV DNA With HPV-Related Oropharynx Cancer

JAMA Otolaryngol Head Neck Surg. 2022 May 1;148(5):488-489. doi: 10.1001/jamaoto.2022.0159.

Authors

Sakshi R Tewari¹, Gypsyamber D'Souza¹, Tanya Troy², Hannah Wright², Linda Struijk³, Tim Waterboer⁴, Carole Fakhry⁵

Affiliations

¹ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
² Department of Otolaryngology Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
³ Viroclinics-DDL Diagnostic Laboratory, Rijswijk, the Netherlands.
⁴ Division of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁵ Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, Maryland.

Abstract

This cross-sectional analysis examines whether circulating tumor human papillomavirus DNA is detectable in the plasma of healthy participants at risk for oral human papillomavirus infection and the agreement with oral rinse and serum biomarkers.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Circulating Tumor DNA* / genetics
DNA, Viral / genetics
Humans
Oropharyngeal Neoplasms*
Oropharynx
Papillomaviridae / genetics
Papillomavirus Infections* / complications

Substances

Circulating Tumor DNA
DNA, Viral

Grants and funding

R35 DE026631/DE/NIDCR NIH HHS/United States