The Relationship of Kidney Tubule Biomarkers with Brain Imaging in CKD Patients in SPRINT

Lindsay M Miller; Manjula Kurella Tamura; Nicholas M Pajewski; Dena Rifkin; Daniel Weiner; Maria Marquine; Michael G Shlipak; Joachim H Ix

doi:10.34067/KID.0007702021

The Relationship of Kidney Tubule Biomarkers with Brain Imaging in CKD Patients in SPRINT

Kidney360. 2021 Dec 8;3(2):337-340. doi: 10.34067/KID.0007702021. eCollection 2022 Feb 24.

Authors

Lindsay M Miller¹, Manjula Kurella Tamura^{2

3

4}, Nicholas M Pajewski⁵, Dena Rifkin^{1

6}, Daniel Weiner⁷, Maria Marquine⁸, Michael G Shlipak^{9

10

11}, Joachim H Ix^{1

6}

Affiliations

¹ Division of Nephrology-Hypertension, University of California San Diego, San Diego, California.
² Department of Medicine-Nephrology, Stanford University, Palo Alto, California.
³ Geriatric Research Education and Clinical Center, Veterans Affairs, Palo Alto, Palo Alto, California.
⁴ Division of Nephrology, Stanford University School of Medicine, Stanford, California.
⁵ Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, North Carolina.
⁶ Nephrology Section, Veterans Affairs San Diego Healthcare System, San Diego, California.
⁷ Department of Medicine, Tufts Medical Center, Boston, Massachusetts.
⁸ Department of Medicine and Psychiatry, University of California San Diego, San Diego, California.
⁹ Division of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, California.
¹⁰ Kidney Health Research Collaborative, Department of Medicine, University of California, San Francisco, San Francisco, California.
¹¹ General Internal Medicine Division, San Francisco Veterans Affairs Healthcare System, San Francisco, California.

Abstract

Urine biomarker concentrations reflecting kidney tubule injury and dysfunction were not associated with brain MRI measures.Higher eGFR was associated with lower total brain cerebral blood flow.This is the first evaluation of the relationship of kidney tubule biomarkers with brain imaging by MRI in patients with CKD.

Keywords: biomarkers; brain; chronic kidney disease; kidney tubules; neuroimaging.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
Brain / diagnostic imaging
Glomerular Filtration Rate / physiology
Humans
Kidney Tubules / injuries
Neuroimaging
Renal Insufficiency, Chronic* / diagnostic imaging

Substances

Biomarkers

Abstract

Publication types

MeSH terms

Substances

Grants and funding