Limit of Detection for Rapid Antigen Testing of the SARS-CoV-2 Omicron and Delta Variants of Concern Using Live-Virus Culture

J Clin Microbiol. 2022 May 18;60(5):e0014022. doi: 10.1128/jcm.00140-22. Epub 2022 Apr 20.

Authors

Sydney Stanley¹, Donald J Hamel¹, Ian D Wolf¹, Stefan Riedel^{2

3}, Sanjucta Dutta², Elisa Contreras^#², Cody J Callahan^#², Annie Cheng², Ramy Arnaout^{2

3

4}, James E Kirby^#^{2

3}, Phyllis J Kanki^#¹

Affiliations

¹ Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
² Department of Pathology, Beth Israel Deaconess Medical Centergrid.239395.7, Boston, Massachusetts, USA.
³ Harvard Medical School, Boston, Massachusetts, USA.
⁴ Division of Clinical Informatics, Department of Medicine, Beth Israel Deaconess Medical Centergrid.239395.7, Boston, Massachusetts, USA.

^# Contributed equally.

No abstract available

Keywords: COVID-19; Delta; Omicron; RT-qPCR; SARS-CoV-2; analytical sensitivity; antigen test; lateral flow assay; limit of detection.

Publication types

Letter

MeSH terms

COVID-19* / diagnosis
Humans
Immunologic Tests
Limit of Detection
SARS-CoV-2* / genetics

Supplementary concepts

SARS-CoV-2 variants