Two cases of ceftriaxone-induced encephalopathy treated by hemoperfusion in hemodialysis patients

Hemodial Int. 2022 Jul;26(3):E27-E30. doi: 10.1111/hdi.13018. Epub 2022 Apr 19.

Abstract

Ceftriaxone is a third-generation cephalosporin commonly used to treat infection. However, encephalopathy is an emerging adverse effect of ceftriaxone infusion. These patients present with various symptoms, including those of neurotoxicity, that typically resolve 1 week after discontinuation of ceftriaxone. We experienced two cases of ceftriaxone-induced encephalopathy that were successfully treated by rapid removal of ceftriaxone by hemoperfusion.

Keywords: antibiotic-associated encephalopathy; ceftriaxone; ceftriaxone-induced encephalopathy; hemoperfusion.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / adverse effects
  • Brain Diseases* / chemically induced
  • Ceftriaxone / adverse effects
  • Hemoperfusion*
  • Humans
  • Neurotoxicity Syndromes* / etiology
  • Renal Dialysis / adverse effects

Substances

  • Anti-Bacterial Agents
  • Ceftriaxone