Transcriptomic Profile of the Mouse Postnatal Liver Development by Single-Nucleus RNA Sequencing

Front Cell Dev Biol. 2022 Apr 6:10:833392. doi: 10.3389/fcell.2022.833392. eCollection 2022.

Jiangshan Xu^{1

2}, Shijie Hao^{1

2}, Quan Shi^{2

3}, Qiuting Deng^{1

2}, Yujia Jiang^{2

4}, Pengcheng Guo^{5

6}, Yue Yuan^{1

2}, Xuyang Shi^{1

2}, Shuncheng Shangguan^{6

7}, Huiwen Zheng^{2

4}, Guangyao Lai^{6

7}, Yaling Huang², Yang Wang², Yumo Song², Yang Liu², Liang Wu^{1

2}, Zhifeng Wang², Jiehui Cheng⁸, Xiaoyu Wei², Mengnan Cheng^{1

2}, Yiwei Lai⁶, Giacomo Volpe⁹, Miguel A Esteban^{2

5

6

10}, Yong Hou², Chuanyu Liu², Longqi Liu^{1

2}

¹ College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
² BGI-Shenzhen, Shenzhen, China.
³ Department of Biology, University of Copenhagen, Copenhagen, Denmark.
⁴ BGI College and Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
⁵ State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
⁶ Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
⁷ Joint School of Life Sciences, Guangzhou Medical University and Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
⁸ Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, China.
⁹ Hematology and Cell Therapy Unit, IRCCS-Istituto Tumori'Giovanni Paolo II', Bari, Italy.
¹⁰ Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China.

No abstract available

Keywords: bile acid synthesis; hepatocyte maturation; liver zonation; postnatal liver development; single-nucleus transcriptomics.