We conducted 2 independent population-based SARS-CoV-2 serosurveys in Yaoundé, Cameroon, during January 27-February 6 and April 24-May 19, 2021. Overall age-standardized SARS-CoV-2 IgG seroprevalence increased from 18.6% in the first survey to 51.3% in the second (p<0.001). This finding illustrates high community transmission during the second wave of COVID-19.
Keywords: COVID-19; Cameroon; SARS-CoV-2; antibodies; coronavirus disease; respiratory infections; seroepidemiologic studies; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.