Blood biomarkers for HIV infection with focus on neurologic complications-A review

Lars Hagberg; Arvid Edén; Henrik Zetterberg; Richard W Price; Magnus Gisslén

doi:10.1111/ane.13629

Blood biomarkers for HIV infection with focus on neurologic complications-A review

Acta Neurol Scand. 2022 Jul;146(1):56-60. doi: 10.1111/ane.13629. Epub 2022 Apr 26.

Authors

Lars Hagberg^{1

2}, Arvid Edén^{1

2}, Henrik Zetterberg^{2

3

4

5

6}, Richard W Price⁷, Magnus Gisslén^{1

2}

Affiliations

¹ Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
² Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.
³ Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
⁴ Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
⁵ UK Dementia Research Institute at UCL, London, UK.
⁶ Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
⁷ Department of Neurology, University of California San Francisco, San Francisco, California, USA.

Abstract

Although clinical examinations, neuroimaging, and cerebrospinal fluid analyses are the most important ways to evaluate the impact of HIV infection on the brain and in diagnosis of opportunistic infections, several blood biomarkers including HIV RNA concentrations, CD4 +T-cell count, and neurofilament light chain protein (NfL) concentration, along with tests for opportunistic infections can provide important information for clinical decisions.

Keywords: HIV; blood biomarkers; neurology.

Publication types

Review

MeSH terms

Biomarkers
HIV Infections* / complications
Humans
Nervous System Diseases*
Neurofilament Proteins / cerebrospinal fluid
Opportunistic Infections*

Substances

Biomarkers
Neurofilament Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding