Chemical constituents from Pterocarpus santalinus and their inhibitory effects on nitric oxide production

Jae Sang Han; Hye Ryeong Hong; Jun Gu Kim; Thi Phuong Linh Le; Yong Beom Cho; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1016/j.fitote.2022.105202

Chemical constituents from Pterocarpus santalinus and their inhibitory effects on nitric oxide production

Fitoterapia. 2022 Jun:159:105202. doi: 10.1016/j.fitote.2022.105202. Epub 2022 Apr 28.

Authors

Jae Sang Han¹, Hye Ryeong Hong¹, Jun Gu Kim¹, Thi Phuong Linh Le¹, Yong Beom Cho¹, Mi Kyeong Lee¹, Bang Yeon Hwang²

Affiliations

¹ College of Pharmacy, Chungbuk National University, Cheongju 28610, Republic of Korea.
² College of Pharmacy, Chungbuk National University, Cheongju 28610, Republic of Korea. Electronic address: byhwang@chungbuk.ac.kr.

PMID: 35489581
DOI: 10.1016/j.fitote.2022.105202

Abstract

A tropolone (2) and an acorane sesquiterpene (3), along with twenty previously known compounds were isolated from the heartwood of Pterocarpus santalinus. The structure of the isolated compounds was elucidated via 1D and 2D NMR spectroscopy and HRESIMS analysis. The absolute configuration of 3 was determined by comparison of the experimental and calculated ECD data. All compounds were evaluated for their inhibitory effects against nitric oxide production in LPS-stimulated RAW 264.7 macrophages.

Keywords: Acorane; Fabaceae; Nitric oxide; Norlignan; Pterocarpus santalinus; Tropolone.

MeSH terms

Macrophages
Molecular Structure
Nitric Oxide
Pterocarpus* / chemistry
Sesquiterpenes* / chemistry
Sesquiterpenes* / pharmacology

Substances

Sesquiterpenes
Nitric Oxide