Efficient synthesis of 1-iodoalkynes via Al2O3 mediated reaction of terminal alkynes and N-iodosuccinimide

Ming Yao; Jingjing Zhang; Sen Yang; Hangxing Xiong; Li Li; E Liu; Hong Shi

doi:10.1039/d0ra00251h

Efficient synthesis of 1-iodoalkynes via Al₂O₃ mediated reaction of terminal alkynes and N-iodosuccinimide

RSC Adv. 2020 Jan 23;10(7):3946-3950. doi: 10.1039/d0ra00251h. eCollection 2020 Jan 22.

Authors

Ming Yao¹, Jingjing Zhang^{1

2}, Sen Yang¹, Hangxing Xiong^{1

2}, Li Li^{1

2}, E Liu¹, Hong Shi¹

Affiliations

¹ Jingchu University of Technology 33 Xiangshan Road Jingmen Hubei 448000 P. R. China yaomingcep@jcut.edu.cn.
² Wuhan Institute of Technology 206 Guanggu First Road Wuhan Hubei 430205 P. R. China.

Abstract

Iodination of terminal alkynes using N-iodosuccinimide (NIS) in the presence of γ-Al₂O₃ was developed to afford 1-iodoalkynes with good to excellent yields (up to 99%). This described approach featured excellent chemoselectivity, good functional group tolerance, and utilization of an inexpensive catalyst.