Aquaporin-4 protein antibody-associated optic neuritis related to neuroendocrine tumor after receiving an inactive COVID-19 vaccine

Indian J Ophthalmol. 2022 May;70(5):1828-1831. doi: 10.4103/ijo.IJO_2494_21.

Abstract

Neuromyelitis optica (NMO), also known as Devic's disease, is a rare, autoimmune, and recurrent demyelinating disorder that primarily affects the spinal cord and optic nerve. We report a case with recurrent optic neuritis caused by the paraneoplastic NMO spectrum disorder in the setting of a gastric neuroendocrine tumor 2 weeks after receiving an inactive COVID-19 vaccine.

Keywords: Aquaporin-4 protein antibody; gastric neuroendocrine tumor; inactive COVID-19 vaccine; optic neuritis.

Publication types

  • Case Reports

MeSH terms

  • Aquaporin 4
  • Autoantibodies
  • COVID-19 Vaccines
  • COVID-19*
  • Humans
  • Neuroendocrine Tumors* / diagnosis
  • Neuromyelitis Optica* / pathology
  • Optic Neuritis* / diagnosis
  • Optic Neuritis* / etiology

Substances

  • Aquaporin 4
  • Autoantibodies
  • COVID-19 Vaccines