Atypical Case of MOG Antibody-Associated Optic Neuritis with Roth Spots

Ocul Immunol Inflamm. 2023 Jul;31(5):1068-1072. doi: 10.1080/09273948.2022.2062386. Epub 2022 May 6.

Abstract

Purpose: To report an atypical case of MOG antibody-associated optic neuritis with Roth spots and widespread retinal hemorrhages.

Case report: A 49-year-old woman complained of 1 week history painful visual loss in the left eye. Funduscopy exam showed a severe optic disc edema associated with multiple peripapillar hemorrhages, peripheral retinal hemorrhages and Roth spots in the left eye. Orbit MRI revealed an hyperintensity in the left optic nerve, enhanced with gadolinium. The serum Myelin Oligodendrocyte (MOG) antibodies was found positive. Early intravenous high dose of steroids rapidly improved visual acuity and fundus abnormalities rapidly resolved.

Conclusion: Retinal hemorrhages can also be detected in case of optic disc edema associated with an optic neuritis, as seen in MOGAD.

Keywords: MOGAD; Roth spots; optic neuritis.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies
  • Female
  • Fundus Oculi
  • Humans
  • Middle Aged
  • Myelin-Oligodendrocyte Glycoprotein / therapeutic use
  • Optic Neuritis* / diagnosis
  • Optic Neuritis* / drug therapy
  • Papilledema* / diagnosis
  • Papilledema* / drug therapy
  • Papilledema* / etiology
  • Retinal Hemorrhage
  • Retrospective Studies

Substances

  • Autoantibodies
  • Myelin-Oligodendrocyte Glycoprotein