PRC1 uncomplexed

Stem Cell Reports. 2022 May 10;17(5):1009-1011. doi: 10.1016/j.stemcr.2022.04.010.

Abstract

Epigenetic enzymes are critically involved in gene regulation during lineage commitment. In this issue of Stem Cell Reports, Zhu et al. (2022) unravel extensive redundancy between subunits of the epigenetic regulatory Polycomb Repressive Complex 1 using a systematic knockout strategy in mouse embryonic stem cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Gene Expression Regulation
  • Mice
  • Mouse Embryonic Stem Cells* / metabolism
  • Polycomb Repressive Complex 1* / genetics
  • Polycomb Repressive Complex 1* / metabolism
  • Polycomb-Group Proteins / genetics

Substances

  • Polycomb-Group Proteins
  • Polycomb Repressive Complex 1