Comparison Between Two Definitions of Contrast-Associated Acute Kidney Injury in Patients With Congestive Heart Failure

Bo Wang; Yiying Zheng; Huanqiang Li; Shuling Chen; Ziyou Zhou; Zhubin Lun; Ming Ying; Lingyu Zhang; Ziling Mai; Liwei Liu; Ziqing Zhou; Mengfei Lin; Yongquan Yang; Jiyan Chen; Yong Liu; Jin Liu; Shiqun Chen; Ning Tan

doi:10.3389/fcvm.2022.763656

Comparison Between Two Definitions of Contrast-Associated Acute Kidney Injury in Patients With Congestive Heart Failure

Front Cardiovasc Med. 2022 Apr 27:9:763656. doi: 10.3389/fcvm.2022.763656. eCollection 2022.

Authors

Bo Wang^{1

2}, Yiying Zheng^{3

4}, Huanqiang Li^{1

2}, Shuling Chen¹, Ziyou Zhou⁵, Zhubin Lun⁶, Ming Ying^{1

2}, Lingyu Zhang⁷, Ziling Mai⁵, Liwei Liu³, Ziqing Zhou⁸, Mengfei Lin⁷, Yongquan Yang^{1

2}, Jiyan Chen^{1

2

3

5}, Yong Liu^{1

2

3

5}, Jin Liu^{1

2

3

5}, Shiqun Chen^{1

2

3

5}, Ning Tan^{1

2

3

5}

Affiliations

¹ Department of Cardiology, Guangdong Provincial People's Hospital, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, China.
² Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, China.
³ The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
⁴ Department of Cardiology, People's Hospital of Yangjiang, Yangjiang, China.
⁵ School of Medicine, Guangdong Provincial People's Hospital, South China University of Technology, Guangzhou, China.
⁶ The First School of Clinical Medicine, Guangdong Medical University, Zhanjiang, China.
⁷ Department of Cardiology, Maoming People's Hospital, Maoming, China.
⁸ School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.

Abstract

Background: Different definitions of contrast-associated acute kidney injury (CA-AKI) have different predictive effects on prognosis. However, few studies explored the relationship between these definitions and long-term prognosis in patients with congestive heart failure (CHF). Thus, we aimed to evaluate this association and compared the population attributable risks (PAR) of different CA-AKI definitions.

Methods: This study enrolled 2,207 consecutive patients with CHF undergoing coronary angiography (CAG) in Guangdong Provincial People's Hospital. Two different definitions of CA-AKI were used: CA-AKI_A was defined as an increase ≥.5 mg/dl or > 25% in serum creatinine (SCr) from baseline within 72 h after CAG, and CA-AKI_B was defined as an increase of ≥.3 mg/dl or > 50% in SCr from baseline within 48 h after CAG. Kaplan-Meier methods and Cox regression were applied to evaluate the association between CA-AKI with long-term mortality. Population attributable risk (PAR) of different definitions for long-term prognosis was also calculated.

Results: During the 3.8-year median follow-up (interquartile range 2.1-6), the overall long-term mortality was 24.9%, and the long-term mortality in patients with the definitions of CA-AKI_A and CA-AKI_B were 30.4% and 34.3%, respectively. We found that CA-AKI_A (HR: 1.44, 95% CI 1.19-1.74) and CA-AKI_B (HR: 1.48, 95% CI 1.21-1.80) were associated with long-term mortality. The PAR was higher for CA-AKI_A (9.6% vs. 8%).

Conclusions: Our findings suggested that CA-AKI was associated with long-term mortality in patients with CHF irrespective of its definitions. The CA-AKI_A was a much better definition of CA-AKI in patients with CHF due to its higher PAR. For these patients, cardiologists should pay more attention to the presence of CA-AKI, especially CA-AKI_A.

Keywords: congestive heart failure (CHF); contrast-associated acute kidney injury (CA-AKI); coronary angiography (CAG); long-term all-cause mortality; population attributable risk (PAR).