Restoring type VII collagen in skin

Su M Lwin; John A McGrath

doi:10.1016/j.medj.2022.04.008

Restoring type VII collagen in skin

Med. 2022 May 13;3(5):273-275. doi: 10.1016/j.medj.2022.04.008. Epub 2022 May 13.

Authors

Su M Lwin¹, John A McGrath²

Affiliations

¹ St John's Institute of Dermatology, King's College London (Guy's Campus), London SE1 9RT, UK.
² St John's Institute of Dermatology, King's College London (Guy's Campus), London SE1 9RT, UK. Electronic address: john.mcgrath@kcl.ac.uk.

PMID: 35584643
DOI: 10.1016/j.medj.2022.04.008

Abstract

New therapeutic hope is emerging for people with the rare inherited blistering skin disease recessive dystrophic epidermolysis bullosa (RDEB). Gurevich et al.¹ have reported early-phase clinical trial data evaluating a topical herpes simplex virus 1 vector to restore missing type VII collagen in RDEB skin and heal wounds.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Collagen Type VII* / genetics
Epidermolysis Bullosa Dystrophica* / genetics
Humans
Skin
Wound Healing

Substances

Collagen Type VII