Durability of immune responses to the BNT162b2 mRNA vaccine

Mehul S Suthar; Prabhu S Arunachalam; Mengyun Hu; Noah Reis; Meera Trisal; Olivia Raeber; Sharon Chinthrajah; Meredith E Davis-Gardner; Kelly Manning; Prakriti Mudvari; Eli Boritz; Sucheta Godbole; Amy R Henry; Daniel C Douek; Peter Halfmann; Yoshihiro Kawaoka; Scott D Boyd; Mark M Davis; Veronika I Zarnitsyna; Kari Nadeau; Bali Pulendran

doi:10.1016/j.medj.2021.12.005

Durability of immune responses to the BNT162b2 mRNA vaccine

Med. 2022 Jan 14;3(1):25-27. doi: 10.1016/j.medj.2021.12.005.

Authors

Mehul S Suthar¹, Prabhu S Arunachalam², Mengyun Hu², Noah Reis², Meera Trisal², Olivia Raeber³, Sharon Chinthrajah³, Meredith E Davis-Gardner⁴, Kelly Manning⁴, Prakriti Mudvari⁵, Eli Boritz⁵, Sucheta Godbole⁵, Amy R Henry⁵, Daniel C Douek⁵, Peter Halfmann⁶, Yoshihiro Kawaoka⁷, Scott D Boyd⁸, Mark M Davis⁹, Veronika I Zarnitsyna¹⁰, Kari Nadeau¹¹, Bali Pulendran¹²

Affiliations

¹ Department of Pediatrics, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: msuthar@emory.edu.
² Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
³ Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford, CA, USA.
⁴ Department of Pediatrics, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA.
⁵ Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
⁶ University of Wisconsin, Madison, WI, USA.
⁷ University of Wisconsin, Madison, WI, USA; National Center for Global Health and Medicine, Tokyo, Japan; University of Tokyo, Tokyo, Japan.
⁸ Sean N. Parker Center for Allergy & Asthma Research, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
⁹ Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
¹⁰ Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
¹¹ Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford, CA, USA; Sean N. Parker Center for Allergy & Asthma Research, Stanford, CA, USA.
¹² Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. Electronic address: bpulend@stanford.edu.

Abstract

Antibody responses to the Pfizer-BioNTech mRNA vaccine waned substantially 6 months after the second vaccination.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

MeSH terms

Antibody Formation
BNT162 Vaccine
COVID-19 Vaccines*
COVID-19* / prevention & control
Humans
Vaccines, Synthetic
mRNA Vaccines

Substances

COVID-19 Vaccines
Vaccines, Synthetic
mRNA Vaccines
BNT162 Vaccine

Abstract

Publication types

MeSH terms

Substances

Grants and funding