Susceptibility to Human Immunodeficiency Virus Type 1 Acquisition Linked to Malaria Exposure: A Case-Control Study

Edwin Kamau; Sidhartha Chaudhury; Jessica S Bolton; Bonnie M Slike; Ningbo Jian; Michael A Eller; Leigh Anne Eller; Julie Ake; Merlin L Robb; Shelly J Krebs; Elke S Bergmann-Leitner

doi:10.1093/cid/ciac384

Susceptibility to Human Immunodeficiency Virus Type 1 Acquisition Linked to Malaria Exposure: A Case-Control Study

Clin Infect Dis. 2022 Nov 14;75(10):1834-1837. doi: 10.1093/cid/ciac384.

Authors

Edwin Kamau^{1

2}, Sidhartha Chaudhury³, Jessica S Bolton^{4

5}, Bonnie M Slike^{1

2}, Ningbo Jian^{1

2

4}, Michael A Eller^{1

2}, Leigh Anne Eller^{1

2}, Julie Ake¹, Merlin L Robb^{1

2}, Shelly J Krebs^{1

2}, Elke S Bergmann-Leitner⁵

Affiliations

¹ United States. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
² Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
³ Center for Enabling Capabilities, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
⁴ Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
⁵ Biologics Research and Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.

PMID: 35594548
DOI: 10.1093/cid/ciac384

Abstract

Human immunodeficiency virus (HIV) and malaria infection rates overlap across sub-Saharan Africa, but factors influencing their co-occurrence are unclear. In a case-control study, we investigated whether malaria exposure increases risk of type 1 (HIV-1) acquisition. Prior to seroconverting, HIV-positive cases had significantly higher malaria-associated antibodies compared to HIV-negative controls, linking malaria exposure to HIV-1 acquisition.

Keywords: East Africa; HIV-1 acquisition; HIV-1 susceptibility; Thailand; malaria.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Protozoan
Case-Control Studies
HIV Infections* / complications
HIV Infections* / epidemiology
HIV Seropositivity*
HIV-1*
Humans
Malaria* / epidemiology

Substances

Antibodies, Protozoan