Pearson's patterns correlational of clinical risks at admissions with hospitalization outcomes during initial COVID-19 outbreak

Jingwen Li; Xi Long; Qing Zhang; Xi Fang; Huiling Luo; Fang Fang; Xuefei Lv; Dandan Zhang; Yu Sun; Na Li; Shaoping Hu; Jinghong Li; Nian Xiong; Zhicheng Lin

doi:10.1016/j.isci.2022.104415

Pearson's patterns correlational of clinical risks at admissions with hospitalization outcomes during initial COVID-19 outbreak

iScience. 2022 Jun 17;25(6):104415. doi: 10.1016/j.isci.2022.104415. Epub 2022 May 18.

Authors

Jingwen Li¹, Xi Long², Qing Zhang³, Xi Fang³, Huiling Luo⁴, Fang Fang⁵, Xuefei Lv⁵, Dandan Zhang⁵, Yu Sun⁵, Na Li³, Shaoping Hu⁵, Jinghong Li⁶, Nian Xiong^{1

3}, Zhicheng Lin⁷

Affiliations

¹ Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
² Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
³ Wuhan Red Cross Hospital, Wuhan, Hubei, China.
⁴ Department of Anesthesiology, Wuhan Red Cross Hospital, Wuhan, Hubei, China.
⁵ Department of Radiology, Wuhan Red Cross Hospital, Wuhan, Hubei, China.
⁶ Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
⁷ McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.

Abstract

COVID-19 outbreaks have crushed our healthcare systems, which requires clinical guidance for the healthcare following the outbreaks. We conducted retrospective cohort studies with Pearson's pattern-based analysis of clinical parameters of 248 hospitalized patients with COVID-19. We found that dysregulated neutrophil densities were correlated with hospitalization duration before death (p = 0.000066, r = -0.45 for % neutrophil; p = 0.0001, r = -0.47 for neutrophil count). As such, high neutrophil densities were associated with mortality (p = 4.23 × 10^-31 for % neutrophil; p = 4.14 × 10^-27 for neutrophil count). These findings were further illustrated by a representative "second week crash" pattern and validated by an independent cohort (p = 5.98 × 10^-11 for % neutrophil; p = 1.65 × 10^-7 for neutrophil count). By contrast, low aspartate aminotransferase (AST) or lactate dehydrogenase (LDH) levels were correlated with quick recovery (p ≤ 0.00005). Collectively, these correlational at-admission findings may provide healthcare guidance for patients with COVID-19 in the absence of targeted therapy.

Keywords: Clinical finding; Health sciences; Risk factor.