Inter-personal violence (whether intra- or inter-group) is a pervasive yet highly variable human behavior. Evolutionary anthropologists suggest that the abundance and distribution of resources play an important role in influencing differences in rates of violence, with implications for how resource conditions structure adaptive payoffs. Here, we assess whether differences in large-scale ecological conditions explain variability in levels of inter-personal human violence. Model results reveal a significant relationship between resource conditions and violence that is mediated by subsistence economy. Specifically, we find that interpersonal violence is highest: (1) among foragers and mixed forager/farmers (horticulturalists) in productive, homogeneous environments, and (2) among agriculturalists in unproductive, heterogeneous environments. We argue that the trend reversal between foragers and agriculturalists represents differing competitive pathways to enhanced reproductive success. These alternative pathways may be driven by features of subsistence (i.e., surplus, storage, mobility, privatization), in which foragers use violence to directly acquire fitness-linked social payoffs (i.e., status, mating opportunities, alliances), and agriculturalists use violence to acquire material resources that can be transformed into social payoffs. We suggest that as societies transition from immediate return economies (e.g., foragers) to delayed return economies (e.g., agriculturalists) material resources become an increasingly important adaptive payoff for inter-personal, especially inter-group, violence.