A novel link between locus coeruleus activity and amyloid-related cognitive decline

Trends Neurosci. 2022 Sep;45(9):651-653. doi: 10.1016/j.tins.2022.05.006. Epub 2022 May 31.

Abstract

Recent work from Prokopiou, Engels-Domínguez et al. assessed locus coeruleus (LC) activity and its functional connectivity (FC) to forebrain regions during a novelty task in cognitively unimpaired adult individuals with varying degrees of amyloid deposition. Novelty increased LC activity and LC FC, but lower responses on these measures were associated with steeper cognitive decline in amyloid-positive individuals.

Keywords: Alzheimer’s disease; aging; fMRI; functional connectivity; novelty.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Adult
  • Alzheimer Disease*
  • Amyloid beta-Peptides
  • Cognitive Dysfunction*
  • Humans
  • Locus Coeruleus / physiology
  • Magnetic Resonance Imaging
  • Positron-Emission Tomography

Substances

  • Amyloid beta-Peptides