Disseminated Lyme disease and dilated cardiomyopathy: A systematic review

Mehras Motamed; Kiera Liblik; Andres F Miranda-Arboleda; Rachel Wamboldt; Chang Nancy Wang; Oscar Cingolani; Alison W Rebman; Cheryl B Novak; John N Aucott; Juan M Farina; Adrian Baranchuk

doi:10.1016/j.tcm.2022.05.010

Disseminated Lyme disease and dilated cardiomyopathy: A systematic review

Trends Cardiovasc Med. 2023 Nov;33(8):531-536. doi: 10.1016/j.tcm.2022.05.010. Epub 2022 Jun 3.

Authors

Affiliations

¹ Department of Medicine, Kingston Health Science Centre, Queen's University, Kingston General Hospital K7L 2V7, Kingston, ON, Canada.
² Department of Medicine, Kingston Health Science Centre, Queen's University, Kingston General Hospital K7L 2V7, Kingston, ON, Canada; Cardiology Department, Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia.
³ Division of Cardiology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
⁴ Lyme Disease Research Center, Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁵ Department of Cardiovascular and Thoracic Surgery, Mayo Clinic, Phoenix, AZ, USA.
⁶ Department of Medicine, Kingston Health Science Centre, Queen's University, Kingston General Hospital K7L 2V7, Kingston, ON, Canada. Electronic address: Adrian.Baranchuk@kingstonhsc.ca.

PMID: 35667636
DOI: 10.1016/j.tcm.2022.05.010

Abstract

Lyme carditis is a well-established manifestation of early disseminated Lyme infection, yet the relationship between late disseminated Lyme disease and the development of dilated cardiomyopathy (DCM) remains unclear. The present systematic review aims to summarize existing literature on the association between late disseminated Lyme disease and DCM. A systematic review was conducted in PubMed, Embase, CENTRAL, and MEDLINE databases, after which a total of 11 observational studies (n = 771) were ultimately included for final data extraction. Although most studies (7/11) identified evidence associating Borrelia-infection with DCM, further research is required to isolate late disseminated Borrelia infection as a causative agent of DCM.

Keywords: Borrelia burgdorferi; Carditis; Dilated cardiomyopathy; Lyme disease.

Publication types

Systematic Review
Review

MeSH terms

Cardiomyopathy, Dilated* / diagnosis
Cardiomyopathy, Dilated* / etiology
Humans
Lyme Disease* / diagnosis
Lyme Disease* / epidemiology