A prospective, one-year follow-up study of patients newly diagnosed with neurosarcoidosis

Keld-Erik Byg; Zsolt Illes; Tobias Sejbaek; Nina Nguyen; Sören Möller; Kate L Lambertsen; Helle H Nielsen; Torkell Ellingsen

doi:10.1016/j.jneuroim.2022.577913

A prospective, one-year follow-up study of patients newly diagnosed with neurosarcoidosis

J Neuroimmunol. 2022 Aug 15:369:577913. doi: 10.1016/j.jneuroim.2022.577913. Epub 2022 Jun 9.

Authors

Keld-Erik Byg¹, Zsolt Illes², Tobias Sejbaek³, Nina Nguyen⁴, Sören Möller⁵, Kate L Lambertsen⁶, Helle H Nielsen², Torkell Ellingsen⁷

Affiliations

¹ Rheumatology Research Unit, Odense University Hospital, J.B. Winsloewsvej 4, 5000 Odense, Denmark; Department of Neurology, Odense University Hospital, J.B. Winsloewsvej 4, 5000 Odense, Denmark; BRIDGE-Brain Research-Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, J.B. Winsloewsvej 19, 5000 Odense, Denmark; Department of Clinical Research, University of Southern Denmark, J.B. Winsloewsvej 19, 5000 Odense, Denmark. Electronic address: keld-erik.byg@rsyd.dk.
² Department of Neurology, Odense University Hospital, J.B. Winsloewsvej 4, 5000 Odense, Denmark; BRIDGE-Brain Research-Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, J.B. Winsloewsvej 19, 5000 Odense, Denmark; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsloewsvej 21, 5000 Odense, Denmark.
³ BRIDGE-Brain Research-Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, J.B. Winsloewsvej 19, 5000 Odense, Denmark; Department of Neurology, South West Jutland University Hospital of Southern Denmark, Finsensgade 35, 6700 Esbjerg, Denmark; Department of Regional Health Research, University of Southern Denmark, J.B. Winsloewsvej 19, 5000 Odense, Denmark.
⁴ Department of Radiology, Odense University Hospital, J.B. Winsloewsvej 4, 5000 Odense, Denmark.
⁵ Department of Clinical Research, University of Southern Denmark, J.B. Winsloewsvej 19, 5000 Odense, Denmark; Open Patient data Explorative Network, Odense University Hospital, J.B. Winsloewsvej 9a, 5000 Odense, Denmark.
⁶ BRIDGE-Brain Research-Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, J.B. Winsloewsvej 19, 5000 Odense, Denmark; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsloewsvej 21, 5000 Odense, Denmark.
⁷ Rheumatology Research Unit, Odense University Hospital, J.B. Winsloewsvej 4, 5000 Odense, Denmark; Department of Clinical Research, University of Southern Denmark, J.B. Winsloewsvej 19, 5000 Odense, Denmark.

PMID: 35717739
DOI: 10.1016/j.jneuroim.2022.577913

Abstract

Methods: Twenty patients with newly diagnosed neurosarcoidosis were examined for multiple outcomes in an observational cohort study with 12-month follow-up.

Results: The patients' contrast-enhancing lesions on MRI scans reduced during treatment (p < 0.0001). The mean modified Rankin Score improved from 3.0 to 1.8 (p < 0.0001), and 75% of patients experienced clinically important improvement. Patients improved on the Symbol Digit Modalities Test (p < 0.0001) and on SF-36 Physical (p = 0.003) and Mental Component Summary scores (p = 0.03). Proportions of patients with substantial fatigue (75%) and high depression score (35%) were unchanged.

Conclusions: 12-month immunosuppression improved several outcomes, and 75% of patients experienced clinically important improvement.

Keywords: FAS; MRI; Neurosarcoidosis; SDMT; Treatment; mRS.

Publication types

Observational Study

MeSH terms

Central Nervous System Diseases* / diagnostic imaging
Follow-Up Studies
Humans
Neuropsychological Tests
Prospective Studies
Sarcoidosis

Supplementary concepts

Neurosarcoidosis