Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver

Cell Res. 2022 Aug;32(8):773-776. doi: 10.1038/s41422-022-00680-4. Epub 2022 Jun 20.

Authors

Hongtao Liu¹, Rossitza N Irobalieva¹, Rose Bang-Sørensen¹, Kamil Nosol¹, Somnath Mukherjee², Parth Agrawal², Bruno Stieger³, Anthony A Kossiakoff², Kaspar P Locher⁴

Affiliations

¹ Institute of Molecular Biology and Biophysics, ETH Zürich, Zürich, Switzerland.
² Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
³ Department of Clinical Pharmacology and Toxicology, University Hospital Zürich, University of Zürich, Zürich, Switzerland.
⁴ Institute of Molecular Biology and Biophysics, ETH Zürich, Zürich, Switzerland. locher@mol.biol.ethz.ch.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Bile Acids and Salts* / metabolism
Biological Transport
Humans
Liver / metabolism
Sodium / metabolism
Symporters* / metabolism

Substances

Bile Acids and Salts
Symporters
Sodium

Grants and funding

R01 GM117372/GM/NIGMS NIH HHS/United States